Protein synthesis by human platelets.
نویسندگان
چکیده
The present studies show that human platelets can incorporate uniformly labeled W-L-leucine into trichloracetic acid-precipitable material. This material is digested by Pronase but not by deoxyribonuclease or ribonuclease. Acid hydrolysis of the material liberates a compound with chromatographic properties identical with those of authentic r,-leucine. The incorporation of uniformly labeled 14C-~leucine by platelets is inhibited by puromycin but not by actinomycin D. To our knowledge, this study constitutes the f?rst definite demonstration that mammalian platelets can synthesize protein.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 242 9 شماره
صفحات -
تاریخ انتشار 1967